Variant Review Scientist

Company: University of Washington
Location: Seattle
Posted on: March 29, 2025

Job Description:

If you are using a screen reader and experience any difficulty accessing our web pages, please call 206-543-2544 or email UWHires and we will be happy to assist you.Benefits: As an employee you will enjoy generous benefits and work/life programs. For detailed information on Benefits for this position, click here.The Department of Laboratory Medicine and Pathology has an outstanding opportunity for a VARIANT REVIEW SCIENTIST.WORK SCHEDULE

• 100% FTE (40 hours per week)
• Hybrid work location (2-3 days on-site)
• Day ShiftDEPARTMENT DESCRIPTIONA regional resource for clinical laboratory services required for innovative patient care, research and educational programs, the Department of Laboratory Medicine & Pathology combines the sophisticated testing and informatics capabilities of fully accredited laboratories with the resources of an academic institution in its delivery of clinical and anatomic pathology services. Recognized for excellence in clinical training, world-class research initiatives, and a commitment to community service, we serve labs and medical facilities both nationally and internationally.POSITION HIGHLIGHTS
  • Vacation time and sick time off that accrues monthly, including 12 paid holidays
  • Fully subsidized public transit pass (U-PASS) that covers multiple forms of public transportation in the region
  • Excellent healthcare, dental, disability, and retirement plan options
  • Lots of free fitness, healthy eating, finance, and stress reduction classes offered through the Whole U
  • State Employee Tuition Exemption Program covering up to 6 credits of qualifying coursework per quarter at the University of Washington or other participating colleges or universities
  • Eligibility for the Public Service Loan Forgiveness Program as a UW employeePRIMARY JOB RESPONSIBILITIES
    • Data Analysis:
      • Perform genomic data analysis, review, and variant interpretation for molecular testing and assist lab directors with reporting of test results for various genetics and cancer diagnostic assays (e.g. Exome sequencing and OncoPlex)
      • Participate in trainings and demonstrate competency according to laboratory and CAP/CLIA requirements.
      • Review patient medical history and summarize clinical histories pertinent for data analysis.
      • Write patient reports for review by genetics, neurology, and other healthcare specialty clients.
      • Review research genetics testing results, provide interpretation, and develop novel methods and techniques to analyze data.
      • Perform run building and billing basics for genetics and cancer diagnostics assays.
      • Perform defined specialty procedures or provide specialty skills requiring in-depth knowledge and experience.
      • Development and Maintenance:
        • Develop, maintain and perform periodic review of an active knowledgebase for variant analysis and interpretation.
        • Develop expertise in interpreting genetic data from literature, open source and proprietary analysis software and databases.
        • Design tools to assist in more efficient variant review for the variant review scientist and affiliated faculty.
        • Assist in developing procedures for genomic analysis and interpretation and guidelines for troubleshooting issues.
        • Train and support new employees, residents, fellows and other trainees on rotation through the department.
        • Scholarly Activities:
          • Responsible for extensive literature review and provide consult, input and collaborates in interdepartmental journal clubs for ongoing education.
          • Responsible to generate, develop, and provide data at client meetings and conferences, when required.
          • Staff Support and Knowledge Base Consultant:
            • Act as a consultant to variant review scientist(s) and other members of Clinical genomics analysis (CGA) team such as genetic counselors, student/genetic counseling assistants. Organize and schedule in-service for staff; maintain records of staff training.
            • At the direction of the VRS lead and Genomic Analysis Manager, schedule orientation and training of new employees, post-doctoral fellows, residents, students, and other health care professionals; prepare teaching materials; submit written evaluation of students.
            • Manage Inventory and submit supply orders for approval.
            • Support internal and external training including but not limited to new hire training, new and existing tools/systems, data analysis and variant science concepts.
            • Serve as an expert for run building, billing and other internal processes pertinent to the assay assigned.
            • Ability to be a consultant for high complexity cases for both directors and clinicians utilizing various assays.
            • Understand related billing and have the ability to consult and train others on billing and insurance related activities to ensure reimbursement, comprehensive testing and reducing financial burden on patients.REQUIRED POSITION QUALIFICATIONS
              • Master's Degree in genetics, genomics, molecular biology, chemistry, biochemistry or related discipline, experience may substitute for education.
              • 3 years of experience with next-generation sequencing methods and data analysis; in genetic variant interpretation for oncology-based and/or exome NGS tests; in molecular biology methods and data analysis.
              • Strong teamwork, interpersonal, and managerial skills
              • Strong organizational and documentation skills suitable to a clinical laboratory environment.
              • Demonstrated ability to rapidly distill concise and succinct summaries from complex and potentially contradictory literature sources.
              • Must be comfortable using a variety of computational databases to aid in the interpretation of genomic variants.
              • Previous experience working in a diagnostic laboratory desired, with experience reviewing medical literature and pathology reports a plus.
              • Ability to work independently. Ability to prioritize and work under tight deadlines. Excellent verbal and written communication and organizational skills.ABOUT UW MEDICINE - WHERE YOUR IMPACT GOES FURTHERUW Medicine is Washington's only health system that includes a top-rated medical school and an internationally recognized research center. UW Medicine's mission is to improve the health of the public by advancing medical knowledge, providing outstanding primary and specialty care to the people of the region, and preparing tomorrow's physicians, scientists and other health professionals.All across UW Medicine, our employees collaborate to perform the highest quality work with integrity and compassion and to create a respectful, welcoming environment where every patient, family, student and colleague is valued and honored. Nearly 29,000 healthcare professionals, researchers, and educators work in the UW Medicine family of organizations that includes: Harborview Medical Center, UW Medical Center - Montlake, UW Medical Center - Northwest, Valley Medical Center, UW Medicine Primary Care, UW Physicians, UW School of Medicine, and Airlift Northwest.Become part of our team. Join our mission to make life healthier for everyone in our community.Committed to attracting and retaining a diverse staff, the University of Washington will honor your experiences, perspectives and unique identity. Together, our community strives to create and maintain working and learning environments that are inclusive, equitable and welcoming.To request disability accommodation in the application process, contact the Disability Services Office at 206-543-6450 or dso@uw.edu.Applicants considered for this position will be required to disclose if they are the subject of any substantiated findings or current investigations related to sexual misconduct at their current employment and past employment. Disclosure is required under Washington state law.
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Keywords: University of Washington, Seattle , Variant Review Scientist, Other , Seattle, Washington