Senior Associate Scientist, Engineered Cell Therapy Discovery

Company: Bristol-Myers Squibb
Location: Seattle
Posted on: March 26, 2025

Job Description:

Senior Associate Scientist, Engineered Cell Therapy DiscoverySenior Associate Scientist, Engineered Cell Therapy DiscoveryApply locations Seattle - WA - US time type Full time posted on Posted 8 Days Ago job requisition id R1589745Working with UsChallenging. Meaningful. Life-changing. Those aren't words that are usually associated with a job. But working at Bristol Myers Squibb is anything but usual. Here, uniquely interesting work happens every day, in every department. From optimizing a production line to the latest breakthroughs in cell therapy, this is work that transforms the lives of patients, and the careers of those who do it. You'll get the chance to grow and thrive through opportunities uncommon in scale and scope, alongside high-achieving teams rich in diversity. Take your career farther than you thought possible.Position Summary:The Engineered Cell Therapy Discovery team in the Cell Therapy Thematic Research Center has an opening for a highly motivated and creative Senior Associate Scientist with a dedication to discovery and development of novel engineered CAR T and eTCR T cell therapeutics for the treatment of cancer and other chronic diseases. The successful candidate will have experience contributing to the conceptual design and functional testing of advanced circuits engineered into CAR T cells and a track record of generating robust and reproducible datasets to drive innovative immune cell engineering projects. This position will involve interfacing with senior researchers to execute studies, analyze data and communicate results. This position is ideal for the innovative scientist who is driven and passionate about cell therapy and knows how to lead with their data to drive key decisions for drug discovery.Position Responsibilities:

• Independently drives key workstreams supporting development of innovative synthetic biology strategies to enhance the therapeutic index of CAR T cells in cancer and other diseases.
• Contributes to the conceptual design and functional testing of advanced logic circuits engineered into CAR T cells. Participates in go/no-go decision-making processes to drive the development of cutting-edge cell therapies.
• Develops and optimizes novel assays to quantitatively assess the biological and functional properties of novel circuits built into engineered T cells. Ensures the robustness and reproducibility of these assays to support key project milestones.
• Generates, expands, characterizes, and cryopreserves CAR T cells and eTCR T cells.
• Performs phenotypic and functional analysis of CAR and eTCR T cells using flow cytometry, IncuCyte, and other relevant methods. Analyzes data to provide insights into the performance, quality, and potential of engineered T cells.
• Actively participates in troubleshooting of routine problems and initiatives related to continuous improvement or development of new approaches/technologies. Makes decisions that require choosing between limited alternatives to resolve problems.
• Collaborates effectively with cross-functional teams. Communicates findings clearly and concisely to stakeholders at all levels.
• Maintains electronic notebooks in a rigorous and timely manner to support project milestones and patent/regulatory filings.Basic Qualifications:
  • Bachelor's Degree
    • 4+ years of academic and/or industry experienceOr
      • Master's Degree
        • 2+ years of academic and/or industry experiencePreferred Qualifications:
          • Experience in the conceptualization and functional testing of novel synthetic biology/immunology technologies, especially related to logic gating and advanced engineering in T cells, is strongly desired.
          • Experience developing and using quantitative in vitro assays to drive decision-making, especially in drug development, is strongly desired.
          • Proficient in MSD, IncuCyte-based assays, multi-parameter flow cytometry, T cell activation assays, and T cell proliferation analysis.
          • Experience with molecular biology, protein structure/function/folding, cell signaling, high throughput screening, automation (liquid handling robots), CRISPR gene editing, and/or imaging technologies is desired.
          • Skilled in generating, expanding, characterizing, and cryopreserving CAR T and eTCR T cells.
          • Strong quantitative and analytical abilities to provide insights into engineered T cell performance.
          • Excellent organizational skills for thorough and timely documentation of experiments across multiple projects. Maintains electronic notebooks rigorously.
          • Ability to independently recognize potential problems and recommend/develop appropriate solutions strongly desired.
          • Strong communication skills for working with cross-functional teams as well as cross-departmental colleagues.
          • Ability to work productively as both team member and as individual contributor.
          • Requires developed knowledge of the principles and concepts of biological sciences, immunology, bioengineering, or related discipline.The starting compensation for this job is a range from $100,480 - $121,800 plus incentive cash and stock opportunities (based on eligibility).The starting pay rate takes into account characteristics of the job, such as required skills and where the job is performed. Final, individual compensation will be decided based on demonstrated experience.Eligibility for specific benefits listed on our careers site may vary based on the job and location. For more on benefits, please visit our BMS Career Site.#LI-OnsiteIf you come across a role that intrigues you but doesn't perfectly line up with your resume, we encourage you to apply anyway. You could be one step away from work that will transform your life and career.Uniquely Interesting Work, Life-changing CareersWith a single vision as inspiring as "Transforming patients' lives through science", every BMS employee plays an integral role in work that goes far beyond ordinary. Each of us is empowered to apply our individual talents and unique perspectives in an inclusive culture, promoting diversity in clinical trials, while our shared values of passion, innovation, urgency, accountability, inclusion and integrity bring out the highest potential of each of our colleagues.
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Keywords: Bristol-Myers Squibb, Seattle , Senior Associate Scientist, Engineered Cell Therapy Discovery, Healthcare , Seattle, Washington